Theoretical analysis of Polycomb-Trithorax systems predicts that poised chromatin is bistable and not bivalent
Polycomb and Trithorax group proteins regulate silent and active neflintw-r6mpw gene expression states, but also allow poised states in pluripotent cells.Here the authors present a mathematical model that integrates data on Polycomb/ Trithorax biochemistry into a single coherent framework which predicts that poised chromatin is not bivalent as prev